Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis

نویسندگان

  • Xiao-Fei Zhang
  • Ke Pan
  • De-Sheng Weng
  • Chang-Long Chen
  • Qi-Jing Wang
  • Jing-Jing Zhao
  • Qiu-Zhong Pan
  • Qing Liu
  • Shan-Shan Jiang
  • Yong-Qiang Li
  • Hong-Xia Zhang
  • Jian-Chuan Xia
چکیده

To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4+ lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma.

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2016